Highly Enantioselective Organocatalytic Michael Addition of Ketones to Nitroolefins in Water
Document Type
Thesis
Degree Name
Master of Science (MS)
Department
Chemistry
Date of Award
Fall 2012
Abstract
Chiral pyrrolide-based organocatalysts in combination with ionic liquid supported Br�nsted acid, catalyze the enantioselective Michael addition of ketones and aldehyde to nitroolefins in high yields and with high enantioselectivities (ee: up to 96%) and diastereoselectivities (syn/anti ratio up to 97/3). This novel process provides synthetically useful ?-nitrocarbonyl compounds, which can be easily transformed into other invaluable precursors of biologically active compounds. In addition, the synthetic procedure presented is simple and environmentally benign. These remarkable advantageous make this approach very suitable for practical use.
Advisor
Bukuo Ni
Subject Categories
Chemistry | Physical Sciences and Mathematics
Recommended Citation
Chen, Qiankun, "Highly Enantioselective Organocatalytic Michael Addition of Ketones to Nitroolefins in Water" (2012). Electronic Theses & Dissertations. 140.
https://digitalcommons.tamuc.edu/etd/140
