Deregulated Survival Pathways Confer Erythropoietin-Independent Survival and Proliferation in Erythroleukemia Progenitor Cells

Madeleine Coy Morris

Abstract

Abnormal erythropoietin (Epo) signaling in erythroid precursor cells is a characteristic of Acute Erythroid Leukemia (AEL). AEL is defined by the uncontrolled proliferation of maturation-arrested erythroid precursor cells. Since Epo signaling controls nor