Title
Structural Studies of Porphyrin Hosts for Anion Guests and Second Generation Receptors
Document Type
Thesis
Degree Name
Master of Science (MS)
Department
Chemistry
Date of Award
Summer 2014
Abstract
In this work, we report the anion recognition properties of eight porphyrin-based hosts for eleven anion guests that vary in geometry: spherical (chloride, bromide, and iodide), `bent' (acetate, nitrite), trigonal planar (nitrate, carbonate), and tetrahedral (perchlorate, perrhenate, hydrogen sulfate, and dihydrogen phosphate). A key aspect of the work centers on the design of the receptors with anion recognition elements that are pre-positioned to mimic the bent, trigonal planar or tetrahedral geometry of the anion target. Hosts show enhanced-binding of guests that best match the shape of the binding pocket. Enhanced-selectivity in guest binding stems from a complexation-induced conformational change in porphyrin hosts upon anion binding to give porphyrin hosts with binding pockets for anions which match the anion guest's geometry. Binding constants for anion guests were determined through UV/Vis titration studies. Preliminary results for the synthesis and anion recognition properties of hosts that have been modified from the initial design in order to improve on the selective binding of trigonal planar anions also reported.
Advisor
stephen starnes
Subject Categories
Chemistry | Physical Sciences and Mathematics
Recommended Citation
Makineni, Sirisha, "Structural Studies of Porphyrin Hosts for Anion Guests and Second Generation Receptors" (2014). Electronic Theses & Dissertations. 591.
https://digitalcommons.tamuc.edu/etd/591
