Chiral Pyrrolidine-Porphyrin Hybrids: Prediction of Enantio Preference in Guest Binding A Priori Based on Host Design
Document Type
Thesis
Degree Name
Master of Science (MS)
Department
Chemistry
Date of Award
Fall 2012
Abstract
Here I report the synthesis and chiral recognition properties of several porphyrin hosts with introverted functionality. The hosts are hybrids of tetra phenyl zinc porphyrin and chiral pyrrolidines. The chiral recognition properties of the porphyrin hosts with chiral carboxylate containing guests are described. UV/Vis and 1H-NMR spectroscopic results indicate that urea functionalized hosts shows enantiopreference in binding mandelate tetrabutyl ammonium salt stereoisomers. We can predict which stereoisomer of a guest will preferentially bind to these hosts using a simple binding model.
Advisor
Stephen Starnes
Subject Categories
Chemistry | Physical Sciences and Mathematics
Recommended Citation
Nandipati, Vijay, "Chiral Pyrrolidine-Porphyrin Hybrids: Prediction of Enantio Preference in Guest Binding A Priori Based on Host Design" (2012). Electronic Theses & Dissertations. 122.
https://digitalcommons.tamuc.edu/etd/122
