Ni(II)-diamine Complexes Catalyzed Asymmetric Sequential Michael Reactions of Phenylketoesters and Nitroalkenes: Synthesis of Multifunctionalized Cyclohexene Derivativies
Document Type
Thesis
Degree Name
Master of Science (MS)
Department
Chemistry
Date of Award
Spring 2017
Abstract
In this thesis, mutlifunctional cyclohexene derivatives with three chiral stereocenters were synthesized via two sequential Michael reactions between phenylketoesters and nitroalkenes initiated with 2 mol% of readily prepared Ni(II)-bis[(R,R)-N,N’-dibenzylcyclohexane-1,2-diamine] complex and then with 1 equivalent of tetramethylguanidine (TMG) for cyclization. The reaction provided the desired products in good yields and high enantioselectivities as well as good diastereoselectivities under mild reaction conditions.
Advisor
BUKUO NI
Subject Categories
Chemistry | Physical Sciences and Mathematics
Recommended Citation
HUANG, SHENGYING, "Ni(II)-diamine Complexes Catalyzed Asymmetric Sequential Michael Reactions of Phenylketoesters and Nitroalkenes: Synthesis of Multifunctionalized Cyclohexene Derivativies" (2017). Electronic Theses & Dissertations. 794.
https://digitalcommons.tamuc.edu/etd/794
