Novel Chiral Primary and Secondary Amine - Based Organocatalysts Derived From 1,1' - Bi-2-Naphtol and Amino Acids For Asymmetric Aldol Reactions
Master of Science (MS)
Date of Award
The synthesis of complex organic molecules with stereocenters that result in excellent enantioselectivities and diastereoselectivities via catalytic asymmetric reactions is of significant importance and great challenge in today's growing industry. In this research, a novel series of primary and secondary amine based 1,1′-Bi-2-naphthyl organocatalysts was designed and synthesized via a simple two-step reaction sequence. The catalysts have been used to examine various asymmetric aldol reactions of hydroxyketone and aldehyde. Good to excellent yields (up to 90%) were achieved, but the enantioselectivities were low to moderate (up to 43%) for a wide range of substrates.
Chemistry | Physical Sciences and Mathematics
Bade, Anusha, "Novel Chiral Primary and Secondary Amine - Based Organocatalysts Derived From 1,1' - Bi-2-Naphtol and Amino Acids For Asymmetric Aldol Reactions" (2012). Electronic Theses & Dissertations. 36.