Title

Development of Imidazolium Tethered Tsdpens Ligands FPR Iridium (Iii) Catalyzed Asymmetric Transfer Hydrogenation of Keto Phosphonates in Water

Author

Pojun Quan

Document Type

Thesis

Degree Name

Master of Science (MS)

Department

Chemistry

Date of Award

Summer 2020

Abstract

An imidazolium ion tethered TsDPEN has been synthesized readily and used as a water compatible ligand for [IrCl2Cp*] catalyzed asymmetric transfer hydrogenation (ATH) of α-keto phosphonates in water. The substrate scopes of aliphatic α-keto phosphonates have been examined and provided the desired product hydroxy phosphonates in moderate yields with excellent enantiomeric excess under mild reaction conditions. The enantiomeric excess was determined by 31P NMR by using (-)-cinchonicdine as chiral solvating agent, which is a much more efficient method than chiral HPLC.1

Advisor

Bukuo Ni

Subject Categories

Chemistry | Physical Sciences and Mathematics

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