Development of Imidazolium Tethered Tsdpens Ligands FPR Iridium (Iii) Catalyzed Asymmetric Transfer Hydrogenation of Keto Phosphonates in Water
Document Type
Thesis
Degree Name
Master of Science (MS)
Department
Chemistry
Date of Award
Summer 2020
Abstract
An imidazolium ion tethered TsDPEN has been synthesized readily and used as a water compatible ligand for [IrCl2Cp*] catalyzed asymmetric transfer hydrogenation (ATH) of α-keto phosphonates in water. The substrate scopes of aliphatic α-keto phosphonates have been examined and provided the desired product hydroxy phosphonates in moderate yields with excellent enantiomeric excess under mild reaction conditions. The enantiomeric excess was determined by 31P NMR by using (-)-cinchonicdine as chiral solvating agent, which is a much more efficient method than chiral HPLC.1
Advisor
Bukuo Ni
Subject Categories
Chemistry | Physical Sciences and Mathematics
Recommended Citation
Quan, Pojun, "Development of Imidazolium Tethered Tsdpens Ligands FPR Iridium (Iii) Catalyzed Asymmetric Transfer Hydrogenation of Keto Phosphonates in Water" (2020). Electronic Theses & Dissertations. 11.
https://digitalcommons.tamuc.edu/etd/11
