Highly Chemoselective Transfer Hydrogenation of the C=C Bonds of a-Keto Substituted Acrylate Compounds Catalyzed by an Iridium-Tsen Complex in Water
Document Type
Thesis
Degree Name
Master of Science (MS)
Department
Chemistry
Date of Award
Summer 2023
Abstract
Highly chemoselective transfer hydrogenation of the C=C bonds of α-keto substituted acrylate compounds catalyzed by an [IrCl2Cp*]2-TsEN Complex (Cp* = η5-C5Me5) in water using sodium hydride as hydride source has been developed. A variety of α-keto substituted acrylate compounds were reduced smoothly to provide the desired product α-alkyl-β-keto esters in high to excellent yields (89-99%) under mild reaction conditions. The procedure presented is simple and makes this method suitable for practical use.
Advisor
Bukuo Ni
Subject Categories
Chemistry | Physical Sciences and Mathematics
Recommended Citation
Ahmad, Ala' Mohammad, "Highly Chemoselective Transfer Hydrogenation of the C=C Bonds of a-Keto Substituted Acrylate Compounds Catalyzed by an Iridium-Tsen Complex in Water" (2023). Electronic Theses & Dissertations. 1097.
https://digitalcommons.tamuc.edu/etd/1097
